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عمومی::
عامل پیشگیرانه
[0003] The present disclosure relates to a humanized antibody for use in the therapeutic or prophylactic treatment of cognitive disorders, a process of producing the humanized antibody, a therapeutic or prophylactic agent for cognitive disorders using the antibody, and methods for treatment or prevention of cognitive disorders using the therapeutic agents disclosed herein.
More specifically, the present disclosure relates to a novel humanized anti-phosphorylated tau antibody having excellent effect of improving cognitive function, a process of producing the humanized antibody, a therapeutic or prophylactic agent for cognitive disorders containing the humanized antibody, and methods for treatment or prevention of cognitive disorders using the humanized anti-phosphorylated tau antibody.
[0059] The humanized anti-phosphorylated tau antibody according to the present invention exhibits high binding affinity to phosphorylated tau while having significantly reduced antigenicity to the human body, and can effectively be used as a therapeutic or prophylactic agent for cognitive disorders such as tauopathy in a human subject.
However, there is currently suitable animal models for testing tauopathy-associated cognitive function impairment that would allow identification of a therapeutic or prophylactic agent for treating cognitive disorders.
[0058] Accordingly, the present invention is directed to humanized and optimized anti-pSer413 tau antibodies useful as a therapeutic or prophylactic agent for treating cognitive disorders such as tauopathy in a human subject.
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